Continuous chromatographic separation equipment principle:

Continuous chromatographic separation equipment is based on the fact that different substances has different partition coefficients in the system composed of stationary phase and mobile phase and will show different retention time in the use of mobile phase elution process in order to achieve separation. Traditional chromatographic separation technology works in a fixed chromatographic column, where certain amount of material enters first and then different product components will be received in the same outlet at different time points in the role of eluent continuous elution. This is a time and energy consuming. After analysis and improvement, we made the stationary phase resin to be continuous system and achieved the separation through the use of material and stationary phase relative to the speed of movement. Similar to the tortoise and the hare, we refer the fixed phase to be a conveyor belt and the rabbit turtle are compared to two different components of different speed. When the fixed phase was given a driving force in the opposite direction of elution, the speed of conveyor will in the middle of the speed of rabbit and turtle, then fast running rabbit is faster than the fixed phase while the slow running turtle is brought to the back of the conveyor belt. Rabbit and turtle is divided.




　     We can use continuous moving bed system to finish the above process:



Advantages of continuous chromatographic separation equipment:

Integrate all steps that can run continuously and have strong system matching;

Reduce the use of resin and make full use of resin

Extend the service life of the resin

Reduce water and chemical consumption, as well as costs and sewage emissions

Can remove or separate the material with different characteristics, and simplify the process;

Maintain the stability and concentration of the product in the feed liquid;

Can effectively improve the purity and concentration of product liquid, saving the cost of follow-up technology;

The use of multi-column system can be flexible to change the production process;

Compact, small area needed, and easy to install in any location

Fully automated and programmed operation control ensures the stable operation of the equipment.

Rotation speed and flow rate can be adjusted according to practical use.
 
Typical applications of continuous chromatographic separation equipment:

The fructose is separated from crystalline fructose

Separation and purification of Xylitol and Arabinose

Separation and purification of Mannitol and Sorbitol

Separation and purification of glucose and galactose

Separation and purification of arabinose and ribose

Separation and purification of glucose or maltose and high glucose

Separation and purification of maltose and glucose

Isolation of valine and alanine

Separation of raffinose, stachyose, monosaccharide and disaccharide in soybean oligosaccharides

Separation and purification of maltitol and oligosaccharides, sorbitol

Citric acid chromatographic separation

P-xylene adsorption separation

Separation of chiral compounds

Isomers separation
 



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